Labopharm is an emerging leader in optimizing the performance of existing small molecule drugs using its proprietary controlled-release technologies. Safe Harbor Statement under the U. About the Acute Pain Prescription Market The number of prescriptions written for acute pain products (mild-opioids, tramadol, COX-2 inhibitors, non-steroidal anti-inflammatory drugs and combinations forms of these products) in the U. Investors should consult the Company's ongoing quarterly Tramadol and acetaminophen filings and annual reports for additional information on risks and uncertainties relating to these forward-looking statements.

Patients taking monoamine oxidase inhibitors, carbamazepine, quinidine, tricyclic compounds, or selective serotonin reuptake inhibitors were excluded because of Tramadol and acetaminophen potential drug interactions or risk of seizures. Such statements are based on management's current beliefs and expectations and involve a number of known and unknown risks and uncertainties that could cause Teva's future results, performance or achievements to differ significantly from the results, performance or achievements expressed or implied by such forward-looking statements. This press release contains forward-looking statements, which reflect the Company's current expectations tramadol and acetaminophen regarding future events.

Howard-Tripp, President and Chief Executive Officer, Labopharm Inc. Gross margin for the first quarter of fiscal 2008 increased to 56% from 50% for the first quarter of fiscal 2007. (TSX: DDS; NASDAQ: DDSS) today announced that it has begun enrolling patients in its Phase III clinical trial for its twice-daily, tramadol-acetaminophen combination product (study 06CCL3-001). CONTACT: At Labopharm: Mark D'Souza, Chief Financial Officer, Tel: (450) 686-0207; At The Equicom Group: Jason Hogan, Media and Investor Relations, tramadol and acetaminophen tel: (416) 815-0700, jhogan@equicomgroup. Com; French: Eric Bouchard, tramadol and acetaminophen tel: (514) 844-7997, ebouchard@equicomgroup. Com * EVIDENCE-BASED ANSWER Tramadol (Ultram, generic and tramadol and acetaminophen with acetaminophen in Ultracet) carries a risk of substance abuse (strength of recommendation [SOR]: B, based on case report surveillance programs). Six patients, 3 from each group, dropped out because of insufficient analgesia (P = ns). While it has been studied in comparison with other analgesics for postoperative pain, there have been no studies looking at comparable efficacy for acute outpatient pain management. This dosage presentation may be particularly advantageous for a drug that is taken multiple times per day (up to 8 tablets per day) tramadol and acetaminophen and is further evidence of Biovail's commitment to providing innovative treatment options for pain management. Blood-thinning drugs such as aspirin and warfarin (Coumadin) can make you bruise more easily because they affect blood clotting. Teva's Tramadol and Acetaminophen Tablets are the AB-rated generic equivalent of Ortho McNeil's Ultracet(R) Tablets, a product indicated for the short-term management of tramadol and acetaminophen acute pain. Par Pharmaceutical began selling a generic version of Ultracet in April without waiting for court approval and Johnson & Johnson has an agreement with Ivax that would let Ivax sell an unbranded version of the drug.
Growth in the broader tramadol market(1) was particularly strong in tramadol and acetaminophen france and Spain, where market share in February 2008 reached 6. 8% and 17. 4%, respectively. Tramadol and acetaminophen asserted against Caraco are invalid. While it appears that tramadol's risk of substance abuse is low (SOR: B, based on case report surveillance programs), tramadol is associated with a withdrawal syndrome usually typical of opioid withdrawal (SOR: B, based on case report surveillance programs, and a prospective descriptive study).